RESEARCH

The Nautiyal Lab studies the neural basis of impulsivity. Impulsive behaviors are characterized as lacking in lack self-control. The ability to delay gratification and suppress responses are both facets of a multi-dimensional construct of impulsivity. Dysregulated impulsive behavior is a key component in a number of psychiatric disorders including ADHD, binge eating, substance use disorders, and behavioral addictions like gambling disorder. Our focus is on the serotonergic modulation of the neural circuits that control impulsive and aggressive behavior. We use a number of approaches to better understand how the brain controls self-control.

GENETIC LOSS-OF-FUNCTION MODELS

Using transgenic mouse lines and viral-vector induced knockouts, we can investigate the effect of serotonin signaling on impulsive behavior and the underlying neural circuits.

BEHAVIOR

Our lab is focused on the careful analysis of behavior in rodent models. We use operant behavioral paradigms to measure a number of different facets of impulsive and reward-related behavior. Additionally, we use and develop other measures of aggressive and depressive behavior.

IN VIVO CALCIUM IMAGING

Using state-of-the-art technology, we can visualize the activity of large populations of neurons at the single-cell level, in awake behaving mice. We use miniature microendoscopes which allow us to view fluorescence emitted from a GFP-fused calcium indicator.