A Behavioral Neuroscience Lab in the Department of Psychological and Brain Sciences at Dartmouth College

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Serotonin modulation of dysregulated reward behavior

The Nautiyal Lab is interested in understanding how serotonin influences neural circuits that subserve reward-related behaviors, including those dysregulated in psychiatric conditions like depression and increased impulsivity.



Nautiyal K.M., Yaden D.B. Does the trip matter? (2022) Investigating the role of the subjective effects of psychedelics in persisting therapeutic effects. Neuropsychopharmacology. doi: 10.1038/s41386-022-01424-z

Carazo Arias, C., Nguyen, P.T., Kass, M.D., Jee, H.J., Nautiyal, K.M., Magalong, V., Coie, L.A., Andreu, V., Gergues, M.M., Khalil, H., Akil,H., Arcego, D.M., Meany, M.J., Anacker, C., Samuels, B.A., Pintar, J.E., Morozova, I., Kalachikov, S., Hen, R. (2022) Contribution of the opioid system to the antidepressant effects of fluoxetine. Biological Psychiatry. doi: 10.1016/j.biopsych.2022.05.030

Li, L., Wyler, S., Leon-Mercado, L., Xu, B., Oh, Y., Chen, X., Wan, R., Arnold, A.G., Jia, L., Nautiyal, K., Hen, R., Sohn, J.-W., Liu, C. (2022) Delineating a serotonin receptor pathway for appetite suppression in mice. Journal of Experimental Medicine. 219(8). PubMed PDF

Desrochers, S.S., Spring, M.G., Nautiyal, K.M. (2022) A role for serotonin in modulating opposing drive and brake circuits of impulsivity. Frontiers in Behavioral Neuroscience 16:791749. PubMed PDF


Li, Y., Simmler, L.D., Zessen, R.V., Flakowski, J., Wan, J.-X., Deng, F., Li, Y.-L., Nautiyal, K.M., Pascoli, V., and Lüscher, C. (2021) Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction. Science 373, 1252-1256. PubMed PDF

Han, J., Andreu, V., Langreck, C., Pekarskaya, E.A., Grinnell, S.G., Magalong, V.M., Pintar, J., Kieffer, B.L., Harris, A.Z., Javitch, J.A., Hen, R., Nautiyal, K.M. (2021) Mu Opioid Receptors on Hippocampal GABAergic Interneurons are Critical for the Antidepressant Effects of Tianeptine. Neuropsychopharmacology. 47(7):1387-1397. PubMed PDF

Desrochers, S.S., Lesko, E.M., Magalong, V.M., Balsam, P.D., Nautiyal, K.M. (2021) A role for reward valuation in the serotonergic modulation of impulsivity. Psychopharmacology (Berl). Aug 14. doi: 10.1007/s00213-021-05944-2. Epub ahead of print. PubMed PDF


Lee,J.H., Capan, S., Lacefield, C., Shea,Y.M., Nautiyal, K.M (2020) DIY-NAMIC Behavior: A High-Throughput Method to Measure Complex Phenotypes in the Homecage. eNeuro 7(4). PubMed PDF


Nautiyal, K.M., Okuda, M., Hen, R., Blanco, C. (2017) Gambling Disorder: An integrative review of animal and human studies. Ann N Y Acad Sci 1394(1):106-127. PubMed PDF

Zike, I.D., Chohan, M.O., Kopelman, J.M., Krasnow, E., Flicker, D., Nautiyal, K.M., Bubser, M., Kellendonk, C., Jones, C.K., Stanwood, G.D., Tanaka, K.F., Moore, H., Ahmari, S.E., Veenstra-VanderWeele, J. (2017) OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity

and stereotypic behavior. Proc Natl Acad Sci U S A 114(22):5719-5724. PubMed PDF

Samuels, B.A.*, Nautiyal, K.M.*, Kruegel, A. C., Levinstein, M.R., Magalong, V.M., Gassaway, M.M., Grinnell, S.G., Han, J., Ansonoff, M.A., Pintar, J.E., Javitch, J.A., Sames, D., Hen, R. (2017) The behavioral effects of the antidepressant tianeptine require the mu-opioid receptor. Neuropsychopharmacology 42(6):1182-1191. *co-first authors PubMed PDF

Nautiyal, K.M., Hen, R. (2017) Serotonin receptors in depression: From A to B. F1000 Faculty Reviews 6:123. PubMed PDF

Nautiyal, K.M., Wang, S., Wall, M.W., Ahmari, S.E., Balsam, P.D., Blanco, C., Hen, R. (2017) Genetic and modelling approaches reveal distinct components of impulsive behavior. Neuropsychopharmacology 42(6):1182-1191. PubMed PDF

Nautiyal, K.M., Tritschler, L., Ahmari, S.E. David, D.J., Gardier, A.M., Hen, R.(2016) A lack of serotonin 1B autoreceptors results in a decrease in anxiety and depression-related behaviours. Neuropsychopharmacology 41(12):2941-2950 PubMed PDF

Nautiyal, K.M., Tanaka, K.F., Barr, M.M., Tritschler, L., LeDantec, Y., David, D.J., Gardier, A.M., Blanco, C., Hen, R., Ahmari, S.E. (2015) Distinct circuits underlie the effects of 5-HT1B receptors on aggression and impulsivity. Neuron. 86(3):813-26. PubMed PDF

Knolhoff, A.M., Nautiyal, K.M., Nemes P., Kalachikov, S., Morozov, I., Silver, R., Sweedler, J.V.(2013) Combining small-volume metabolomic and transcriptomic approaches for assessing brain chemistry. Anal Chem. 85(6):3136-43. PubMed PDF

Donaldson, Z.R., Nautiyal, K.M., Ahmari, S.E., Hen, R. (2013) Genetic approaches for understanding the role of serotonin receptors in mood and behavior. Curr Opin Neurobiol. 23: 1-8. PubMed PDF

Nautiyal, K.M., Dailey, C., Jahn, J.L., Rodriguez, E., Sweedler, J.V., Silver, R. (2012) Serotonin of mast cell origin contributes to hippocampal function. Eur J Neurosci. 2012 Aug: 36(3): 2347-59. PubMed PDF

Nautiyal, K.M. Immune cells in the brain. (2012) In: Neuroscience in the 21st Century, Ed. Donald Pfaff, Springer Link. PDF

Nautiyal, K.M., Liu, C., Dong, X., Silver, R. (2011) Blood-borne donor mast cell precursors migrate to mast cell-rich brain regions in the adult mouse. J Neuroimmunol; 240-241:142-6. PubMed PDF

Nautiyal, K.M., McKellar, H., Silverman, A.J., Silver, R. (2009) Mast cell involvement in the hypothermic response to sepsis. Am J Physiol 296(3):R595-602. PubMed PDF

Nautiyal, K.M., Ribeiro, A., Pfaff, D.W., Silver, R. (2008) Brain mast cells link the immune system to anxiety-like behavior. Proc Natl Acad Sci U S A; 105(46): 18053-57. PubMed PDF

Nautiyal, K.M., Dailey, M., Brito, N., Brito, M.N., Harris, R.B, Bartness, T.J., Grill, H.J. (2008) Energetic responses to cold temperatures in rats lacking forebrain-caudal brainstem connections. Am J Physiol 295(3): R789-98. PubMed PDF